Cells use osmolytes
Cells take in small molecules such as taurine and betaine to adjust their volume, and water follows them. HydroSure includes five amino-acid osmolytes.
How it works
Water follows the osmolytes.
HydroSure pairs five amino-acid osmolytes with creatine. Osmolytes are small molecules your cells use to manage their own water, and water moves to where they are. This page shows the cell biology HydroSure is built on, then each of the six actives with its dose and the reason for it. Whether a supplement changes the water inside cells in healthy people is still an open question.
The mechanism
How cells use osmolytes.
Cells take in small molecules called osmolytes to adjust their volume, and water follows them in. HydroSure is built around that biology, with five amino-acid osmolytes and creatine.
Drag to turn the cell. Slide to add osmolytes and watch water follow. Tap a molecule to see what it is.
Osmolytes in a cell. The molecules shown are the six in HydroSure. Hover or tap one to see what it is.
0%
Cell volume, illustrated
Drag to rotate
Not an electrolyte formula
No added sodium, potassium or magnesium. If you sweat heavily or train in heat, get sodium and fluid from food or a separate product.
Built for every day
Formulated to support daily hydration,* with 5 g of creatine for high-intensity exercise performance.*
An illustration of how cells use osmolytes, not a picture of what HydroSure does in the body. Whether a supplement changes the water inside cells in healthy people is still an open question.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
The six actives
Every dose, and why.
Listed in label order. Each profile gives the form the ingredient comes in, the job it does in the formula and the thinking behind its dose.
5g
L-Alanine
- Form
- Free-form L-alanine, one of the amino acids that make up protein. It is not beta-alanine, so there is no tingle.
- Role
- An amino acid that cells can use as an osmolyte. In cell studies, cells take it up to adjust their volume, and water follows. Much of an oral dose is used by the gut and liver before it reaches other tissues.
- Why 5 g
- Alanine shares the top dose with creatine, which makes it the largest amino-acid osmolyte in the formula. Human research on oral L-alanine and exercise is limited, so we include it for its osmolyte role.
5g
Creatine monohydrate
- Form
- Creatine monohydrate, the form used in most creatine research.
- Role
- Muscle cells take up creatine through a dedicated transporter. It supports high-intensity exercise performance,* and in studies that began with a high-dose week it raised total body water.
- Why 5 g
- Creatine research commonly uses 3 to 5 g a day to maintain muscle creatine stores. HydroSure uses the top of that range. Without a high-dose start, stores fill over about 3 to 4 weeks.
4g
Glycine
- Form
- Free-form glycine, the simplest amino acid.
- Role
- Cells can use glycine as an osmolyte, one of the small molecules a cell uses to manage its water. Most of that evidence comes from cell studies.
- Why 4 g
- At 4 g, glycine is the third-largest dose in the formula, behind alanine and creatine.
3g
Taurine
- Form
- Taurine, an amino sulfonic acid. The body makes some on its own and gets the rest from food.
- Role
- One of the main osmolytes in muscle. Many cell types use taurine to adjust how much water they hold.
- Why 3 g
- 3 g sits within the range used in taurine research. Research on taurine and exercise performance is mixed, so HydroSure makes no performance claim for it.
3g
L-Glutamine
- Form
- Free-form L-glutamine.
- Role
- The most abundant free amino acid in the body. Cells can use it as an osmolyte; that evidence comes mostly from cell studies.
- Why 3 g
- A supporting amount, well below the doses used in recovery trials, so HydroSure makes no recovery claim for it.
1g
Betaine
- Form
- Betaine, also called trimethylglycine or TMG.
- Role
- An osmolyte and a methyl donor.
- Why 1 g
- A supporting role. Studies of betaine and strength or power output used about 2.5 g a day, and 1 g is below that. So HydroSure includes it for its osmolyte role and makes no performance claim for it.
† Daily Value not established for any of the six. The only other ingredient is silicon dioxide. See the full Supplement Facts panel on the product page.
Not in the tub
What it leaves out.
Six actives, and one other ingredient: silicon dioxide, which keeps the powder free-flowing.
Added electrolytes
No added sodium, potassium or magnesium. If you sweat heavily or train in heat, get sodium and fluid from food or a separate product.
Stimulants
No caffeine or any other stimulant on the label. HydroSure is not a pre-workout.
Flavors or sweeteners listed
The label lists no flavors and no sweeteners, natural or artificial. What goes in the water is the six actives and silicon dioxide.
The label
Turn the tub.
This is the real label, wrapped on the canister. Drag to turn it, or jump to a panel.
Net weight23.3 oz (1 lb 7.3 oz) 660 g
DirectionsMix 2 scoops in 64 ounces of water.
CautionConsult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.
StorageKeep out of reach of children. Store in a cool, dry place. Do not use if safety seal is broken or missing.
HydroSure
A cellular hydration formula.*
Five amino-acid osmolytes and 5 g of creatine. 21 grams of actives per serving, not an electrolyte formula, in a 23.3 oz (660 g) tub.
Prices are proposed and pending confirmation. Checkout opens at launch.